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Biosynthesis

Process where substrates are converted into more complex products in living organisms

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This article needs attention from an expert in biochemistry. The specific problem is: someone with a solid grasp of the full scope of this subject and of its secondary and advanced teaching literatures needs to address A, the clear structural issues of the article (e.g., general absence of catabolic biosynthetic pathways, insertion of macromolecule anabolic paths before all building blocks covered, etc.); B, discrepancies in scope vs. other major articles, cf. Nucleic acid metabolism; C, remaining gross factual errors (only those in the lead having yet been superficially addressed); etc..WikiProject Biochemistry may be able to help recruit an expert.(July 2024)

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Biosynthesis, i.e., chemical synthesis occurring in biological contexts, is a term mo

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Bio-organic Synthesis

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop synthetic methodology or as an inspiration for mimetic design.

Sugar Amino Acids (SAA’s) for example have been a major mimetic design interest over the last years in the group. New chemistry is being developed for their construction and to use them as both peptide- and carbohydrate mimics. They have been incorporated in various (cyclic) peptides, such as Gramicidin S, to control their structure and influence their biological properties.

Examples in our drug discovery program include aza-sugar based inhibitors to treat Type II diabetes and well-defined Toll-like Receptor ligands. The chemical biology platform develops new labeling-purification-visualization tools to interrogate the proteome, and the proteasome in particular.

Synthetic carbohydrate chemistry

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(Bio)-Organic Synthesis

The (Bio)-Organic Synthesis cluster consists of 3 research groups:

Publications

Organic Synthesis

The main focus of the Organic Synthesis Research Group is the chemical synthesis and derivatisation of target compounds with non-trivial carbon connectivities, such as those found in polycyclic Natural Products.

The chemical synthesis part mainly involves the development of novel strategies and methods to assemble complex scaffolds, focusing on multiple bond forming steps such as cycloadditions and cascade reactions.
For the chemical derivatisation part, the group focuses on the development of application-oriented versatile covalent ligation reactions to generate multiple derivatives from a single synthetic intermediate.
As a major theme in the recent research, that encompasses both of the above general research topics, the group has started to design and target highly modular synthetic building blocks that allow a rapid exploration of Natural Product-like chemical space using simple and orthogonal functional group transformations.
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